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. . North America colonization When Francisco Coronado and the Spaniards first explored the Rio Grande Valley in 1540 in modern New Mexico some of the chieftains complained of new diseases that affected their tribes Cabeza de Vaca reported that in 1528 when the Spanish landed in Texas "half the natives died from a disease of the bowels and blamed us." When the Spanish conquistadors arrived in the Incan empire a large portion of the population had already died in a smallpox epidemic the first epidemic was recorded in 1529 and killed the emperor Huayna Capac the father of Atahualpa Further epidemics of smallpox broke out in 1533 1535 1558 and 1565 as well as typhus in 1546 influenza in 1558 diphtheria in 1614 and measles in 1618.:133. 4.1 Baseball Spanish control of Texas was followed by Mexican control of Texas and it can be difficult to separate the Spanish and Mexican influences on the future state the most obvious legacy is that of the language; every major river in modern Texas except the Red River has a Spanish or Anglicized name as do 42 of the state's 254 counties Numerous towns also bear Spanish names. Both the American Heart Association and the University of Texas Southwestern Medical Center call Dallas home the Southwestern Medical Center ranks "among the top academic medical centers in the world" the institution's medical school employs the most medical school Nobel laureates in the world. Under orders from Smith Houston successfully dissuaded all but 70 men from continuing to follow Johnson. With his own authority in question following Smith's impeachment Houston washed his hands of the army and journeyed to Nacogdoches to negotiate a treaty with Cherokee leaders Houston vowed that Texas would recognize Cherokee claims to land in East Texas as long as the Indians refrained from attacking settlements or assisting the Mexican army in his absence Fannin as the highest-ranking officer active in the regular army led the men who did not want to go to Matamoros to Goliad, The current Houston Chronicle headquarters formerly the Houston Post headquarters, 4 External links Arts and literature.

The Carnegie Foundation classifies three of Texas's universities as Tier One research institutions: the University of Texas at Austin the Texas A&M University and the University of Houston the University of Texas at Austin and Texas A&M University are flagship universities of the state of Texas Both were established by the Texas Constitution and hold stakes in the Permanent University Fund the state has been putting effort to expand the number of flagship universities by elevating some of its seven institutions designated as "emerging research universities" the two expected to emerge first are the University of Houston and Texas Tech University likely in that order according to discussions on the House floor of the 82nd Texas Legislature, Chronology Low flat-roofed rectangular open marble structure has slender eight-story rectangular columns Visible within is a large circular windowless building, Texas lies at the juncture of two major cultural spheres of Pre-Columbian North America the Southwestern and the Plains areas the area now covered by Texas was occupied by three major indigenous cultures which had reached their developmental peak before the arrival of European explorers and are known from archaeology These are:. The University of Houston located in the Third Ward is a tier-one public research university and the third-largest institution of higher education in Texas. .